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PIRLINDOLE: A SELECTIVE REVERSIBLE INHIBITOR OF MONOAMINE OXIDASE A. A REVIEW OF ITS PRECLINICAL PROPERTIES

✍ Scribed by J. BRUHWYLER; J.F. LIÉGEOIS; J. GÉCZY

Book ID
118770406
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
104 KB
Volume
36
Category
Article
ISSN
1043-6618

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## 2614W94 [3-(1-trifluoromethyl) ethoxyphenoxathiin 10,10-dioxide] is a selective, reversible inhibitor of monoamine oxidase-A with a competitive mechanism of inhibition and a K i value of 1.6 nM with serotonin as substrate. In pretreated rats, the ED 50 value after single oral dosing was 1.7 mg/