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A restricted spectrum of NRAS mutations causes Noonan syndrome

✍ Scribed by Lepri, Francesca; Merbitz-Zahradnik, Torsten; König, Rainer; Cirstea, Ion C; Kutsche, Kerstin; Dvorsky, Radovan; Gremer, Lothar; Carta, Claudio; Horn, Denise; Roberts, Amy E


Book ID
109914548
Publisher
Nature Publishing Group
Year
2009
Tongue
English
Weight
389 KB
Volume
42
Category
Article
ISSN
1061-4036

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## Abstract Noonan syndrome (NS) is the most common non‐chromosomal syndrome seen in children and is characterized by short stature, dysmorphic facial features, chest deformity, a wide range of congenital heart defects and developmental delay of variable degree. Mutations in the Ras/mitogen‐activat