When treated with magnesium bromide, Spiro B-lactones undergo an ionization/elimination reaction to afford cyclohexenyl acetic acid derivatives in high yield and isomeric purity. Cyclohexenyl acetic acid derivatives occupy a position of some importance in organic chemistry, both as synthetic precurs
✦ LIBER ✦
A regioselective synthesis of β-lactones; Bromolactonization of 2-substituted-1-cyclohexenyl-1-acetic acid
✍ Scribed by Sang-sup Jew; Heesoon Lee; Bon-Am Koo
- Book ID
- 112960106
- Publisher
- Springer
- Year
- 1994
- Tongue
- English
- Weight
- 334 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0253-6269
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Z-Substituted 1,2\_dihydropyridines including an optically active one were regioselectively prepared from Z-substituted piperidines through three intermediates, that is, (a) 1,2,3,4\_tetrahydropyridines, (b) 5-bromo-6\_methoxypiperidines, and (c) 1,2,3,6-tetrahydro-6-methoxypyridines. Since 1-acyl-1