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A region flankingH-2Kis duplicated to a distant site in most mousethaplotypes

✍ Scribed by Paul E. Mains

Book ID: 104746136
Publisher: Springer-Verlag
Year: 1986
Tongue: English
Weight: 777 KB
Volume: 23
Category: Article
ISSN: 0093-7711
DOI: 10.1007/bf00372667

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✦ Synopsis

Mouse t haplotypes contain at least one inversion, which encompasses the major histocompatibility complex, relative to their wild-type counterparts. A DNA probe for a single copy sequence which flanks the H-2K region in inbred strains was found to have undergone further rearrangements in the t haplotypes. In most t haplotypes, this sequence is duplicated at a distant site, and the two regions show 1% recombination. The length of homology shared by the two sites is likely to be at least 10-15 kb. Three different alleles, as defined by restriction fragment length polymorphisms, were found for each of the two sites among different t haplotypes. These may reveal evolutionary relationships among these chromosomes.

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