Mapping of the gene for interferon-inducible dsRNA-dependent protein kinase to chromosome region 2p21-22: A site of rearrangements in myeloproliferative disorders
✍ Scribed by Samir M. Hanash; Laura Beretta; Christine L. Barcroft; Susan Sheldon; Thomas W. Glover; David Ungar; Nahum Sonenberg
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 304 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1045-2257
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✦ Synopsis
Recent evidence suggests that the human interferon-inducible double-stranded RNA-dependent protein kinase may function as a tumor suppressor. Here we describe the mapping of the gene for this kinase to chromosome region 2p2 1-22 by fluorescence in situ hybridization. A combined analysis of cytogenetic data from a series of 34 I patients with hematologic disorders that exhibited cytogenetic abnormalities and from published reports indicates that abnormalities involving 2p2 1-22 occur nonrandomly and are observed among patients with acute myelogenous leukemia, raising the possibility of a role for this protein kinase in leukemogenesis.