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A Reagent for the Convenient, Solid-Phase Synthesis of N-Terminal Peptide Hydroxylamines for Chemoselective Ligations

✍ Scribed by Fukuzumi, Takeo; Bode, Jeffrey W.


Book ID
120199832
Publisher
American Chemical Society
Year
2009
Tongue
English
Weight
456 KB
Volume
131
Category
Article
ISSN
0002-7863

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Convenient solid phase synthesis method
✍ N. G. J. Delaet; T. Tsuchida πŸ“‚ Article πŸ“… 1996 πŸ› Springer Netherlands 🌐 English βš– 513 KB

This paper describes a novel solid phase peptide synthesis method for the systematic C-terminal modification of cysteine-containing peptides. In this method, cysteine is linked to chloromethylated polystyrene resin by its thiol functionality, followed by protection of the N-terminus and derivatizati