I have read with great interest the paper by Crowe et al. [1997]. It is an excellent clinical and cytogenetic review of trisomy 22 in its various manifestations. I only wish to point out that the first proven case (by G-banding) of trisomy 22 appeared in 1973, in a paper in which we demonstrated the
A rare case: mosaic trisomy 22
✍ Scribed by Nurettin Basaran; Hakan Berkil; Naim Ay; Beyhan Durak; Caner Ataman; Muhsin Ozdemir; Y Hakan Ozon; Isın Kaya
- Book ID
- 113987271
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 99 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0003-3995
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In a case of mosaic trisomy 22 the trisomic cells were detected primarily in fibroblasts. Results of initial lymphocyte chromosome analysis were normal. However, mosaicism was suspected because the patient had hypomelanosis of Ito, hemiatrophy, failure to thrive, and mental retardation. Mosaicism wa
An 8-year-old male with mental retardation, speech difficulties, and minor congenital anomalies is presented. The clinical findings suggest the trisomy-8 syndrome. The karyotype indicates trisomy-8 mosaicism with trisomic as well as normal cell lines in blood lymphocytes.