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A rapid screening and diagnosis on fragile X syndrome by PCR

✍ Scribed by Jingchun, Chen ;Aide, Yang ;Hongbao, Fei ;Runming, Jin ;Meijuan, He ;Biyu, Wang


Publisher
Springer-Verlag
Year
1999
Tongue
English
Weight
543 KB
Volume
19
Category
Article
ISSN
0257-716X

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Fragile X syndrome is associated with the expansion of the number of CGG trinucleotide tandem repeats at the 5Β’ untranslated region of the FMR1 gene. The number of CGG trinucleotide repeats in normal individuals ranges between 5 and 50, in asymptomatic carrier individuals it ranges between 50 and 20

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## Objective: The objective of this study was to conduct an economic evaluation of routine prenatal carrier testing for fragile X syndrome. Methods: This economic analysis was conducted from the societal perspective. A cost-benefit equation was developed based on the premise that the cost of routi