A rapid, one-pot, four-component route to 2H-indazolo[2,1-b]phthalazine-triones

✍ Scribed by Elaheh Mosaddegh; Asadollah Hassankhani

• Book ID: 104098271
• Publisher: Elsevier Science
• Year: 2011
• Tongue: French
• Weight: 188 KB
• Volume: 52
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2010.08.099

✦ Synopsis

A new, efficient, and environmentally benign protocol for the one-pot, four-component synthesis of 2,2dimethyl-13-phenyl-2,3-dihydro-1H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione by condensation of phthalic anhydride, hydrazinium hydroxide, aromatic aldehydes, and dimedone catalyzed by Ce(SO 4 ) 2 Á4H 2 O as an ecofriendly catalyst with high catalytic activity and reusability at 125 °C under solvent-free conditions is reported. The reaction proceeds to completion within 5-10 min in 71-95% yield. To the best of our knowledge, this new procedure provides the first example of an efficient synthetic method for 2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione via a four-component reaction.