✦ LIBER ✦

A rapid method for the synthesis of 5-iodo-2′- deoxyuridine (IUDR) and optimisation of the parameters

✍ Scribed by Mahendra A. Trivedi

Publisher: John Wiley and Sons
Year: 1993
Tongue: French
Weight: 200 KB
Volume: 33
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580330707

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✦ Synopsis

Abstract

A modified method for the synthesis of radioiodinated 5‐iodo‐2′‐deoxyuridine based on electrophillic iodination using concentrated HNO~3~ as an oxidising agent is described. It is easy, quick, reproducible and yields consistently high (>95%) radiolabelled IUDR. This method avoids refluxing at high temperatures, thereby saving preparation time and improving safety.

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