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A randomized study of methotrexate, bleomycin, hydroxyurea with versus without cisplatin in patients with previously untreated and recurrent squamous cell carcinoma of the head and neck

โœ Scribed by Abele, R.; Honegger, H.P.; Grossenbacher, R.; Mermillod, B.; Kaplan, E.; Gervasi, A.; Wolfensberger, M.; Lehmann, W.; Cavalli, F.


Book ID
123241925
Publisher
Elsevier Science
Year
1987
Weight
634 KB
Volume
23
Category
Article
ISSN
0277-5379

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## For the EORTC Head and Neck Cooperative Group A total of 185 eligible patients with advanced inoperable squamous cell carcinoma of the head and neck were randomized into two groups; the cisplatin, methotrexate, bleomycin, and vincristine (CABO) group received cisplatin (50 mg/m2; day 4), methot

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A combination of cisplatin, methotrexate, bleomycin, and vincristine (CABO) was assessed in advanced epidermoid head and neck cancer. Among 72 patients with recurrent or metastatic disease and measurable lesions, there were 9 complete and 27 partial responses for an overall response rate of 50%. The