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A randomized multicenter phase II clinical trial of mitoxantrone-loaded nanoparticles in the treatment of 108 patients with unresected hepatocellular carcinoma

โœ Scribed by Qinghua Zhou; Xun Sun; Lingyuan Zeng; Jie Liu; Zhirong Zhang


Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
151 KB
Volume
5
Category
Article
ISSN
1549-9634

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โœฆ Synopsis


From the clinical editor:

Intravenous administration of mitoxantrone-loaded polybutylcyanacrylate nanoparticles (dhad-pbca-nps) allows increased cytotoxicity in hepatic tumors and prolonged the median survival periods to 5.46 months compared to 3.23 months in controls.


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## Abstract ## BACKGROUND The treatment of patients with hepatocellular carcinoma (HCC) presents a major challenge, because associated cirrhosis limits the choice of chemotherapeutic agents. However, the abundant vascularity of HCC presents an attractive target for antiangiogenic therapy that pote