This double-blind randomized pilot study aimed to compare the ecacy and the tolerability of pirlindole (150±225 mg/day), a reversible inhibitor of monoamine oxidase A, and mianserin (60±90 mg/day) in the treatment of major depression. Forty patients were included in the trial (20 pirlindole and 20 m
A randomized controlled single blind study of the efficacy of clonazepam and lithium in the treatment of acute mania
✍ Scribed by Helen M. Clark; Michael Berk; Shlomo Brook
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 99 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0885-6222
No coin nor oath required. For personal study only.
✦ Synopsis
This study is a randomized controlled trial of 40 patients suering from bipolar aective disorder, manic phase (DSM IV). The patients were treated with either clonazepam or lithium. There were no dierences between the two groups at 4 weeks on any of the ecacy measures, which included the BPRS, MAS, CGI and GAF scales. Side-eects were comparably mild in both groups. Clonazepam may be an eective treatment for acute mania.
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