A randomized controlled pilot study of Pentoxifylline in patients with non-alcoholic steatohepatitis (NASH)
โ Scribed by Yin-Mei Lee; Dede S. Sutedja; Chun-Tao Wai; Yock-Young Dan; Myat-Oo Aung; Lei Zhou; Chee-Leong Cheng; Aileen Wee; Seng-Gee Lim
- Book ID
- 107593757
- Publisher
- Springer-Verlag
- Year
- 2008
- Tongue
- English
- Weight
- 210 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1936-0533
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## Summary **Background** :โIncreased insulin resistance is the major pathogenic mechanism in the development of nonโalcoholic steatohepatitis. **Aim** :โTo investigate the therapeutic effect of metformin, a wellโknown insulinโsensitizing agent, in the treatment of nonโalcoholic steatohepatitis.
Non-alcohol-induced steatohepatitis (NASH) is characterized by elevated serum aminotransferase activities with hepatic steatosis, inflammation, and occasionally fibrosis that may progress to cirrhosis. No established treatment exists for this potentially serious disorder. Our aim was to conduct a pi