A radical cyclization strategy for the concise total synthesis of (±)-geissoschizine

✍ Scribed by Hiromitsu Takayama; Fumio Watanabe; Mariko Kitajima; Norio Aimi

• Publisher: Elsevier Science
• Year: 1997
• Tongue: French
• Weight: 235 KB
• Volume: 38
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(97)01186-6

✦ Synopsis

A short synthetic route to (+)-geissoschizine (1) was developed that features the construction of a Corynanthe-skeleton via radical cyclization of vinyl iodide, which was easily prepared by assembly of three fragments. New pentacyclic molecules formed by the radical cyclization were also reported.