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A Radical Cyclization Approach to Isoindolobenzazepines. Synthesis of Lennoxamine †

✍ Scribed by Rodríguez, Gema; Cid, M. Magdalena; Saá, Carlos; Castedo, Luis; Domínguez, Domingo

Book ID
127114348
Publisher
American Chemical Society
Year
1996
Tongue
English
Weight
189 KB
Volume
61
Category
Article
ISSN
0022-3263

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A new approach to isoindolobenzazepines
A new approach to isoindolobenzazepines via a ring-expansion of isoindoloisoquinoline: Synthesis of lennoxamine and chilenine
✍ Yuji Koseki; Shuichi Kusano; Harumi Sakata; Tatsuo Nagasaka 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 217 KB

A convenient short-step synthesis of lennoxamine 1 and chilenine 2 is described. The key steps are the preparation of an acyliminium ion precursor and a novel expansion of the six-membered ring to a seven-membered ring.