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A New Approach to Isoindolobenzazepines. A Simple Synthesis of Lennoxamine

โœ Scribed by Axel Couture; Eric Deniau; Pierre Grandclaudon; Christophe Hoarau


Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
163 KB
Volume
56
Category
Article
ISSN
0040-4020

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A new approach to isoindolobenzazepines
โœ Yuji Koseki; Shuichi Kusano; Harumi Sakata; Tatsuo Nagasaka ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 217 KB

A convenient short-step synthesis of lennoxamine 1 and chilenine 2 is described. The key steps are the preparation of an acyliminium ion precursor and a novel expansion of the six-membered ring to a seven-membered ring.