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A radiation hybrid map of bovine chromosome 24 and comparative mapping with human chromosome 18

✍ Scribed by E. Kurar; J. E. Womack; B. W. Kirkpatrick

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
305 KB
Volume
34
Category
Article
ISSN
0268-9146

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✦ Synopsis

Summary

We present herein a bovine chromosome 24 (BTA24) radiation hybrid (RH) map using 40 markers scored on a panel of 90 RHs. Of these markers, 29 loci were ordered with odds of at least 1000:1 in a framework map. An average retention frequency of 17.4% was observed, with relatively higher frequencies near the centromere. The length of the comprehensive map was 640 centiray~5000~ (cR~5000~) with an average marker interval of approximately 17.3 cR~5000~. The observed locus order is generally consistent with currently published bovine linkage and physical maps. Nineteen markers were either Type I loci or closely associated with expressed sequences and thus could be used to compare the BTA24 RH map with human mapping information. All genes located on BTA24 were located on human chromosome 18, and previously reported regions of conserved synteny were extended. The comparative data revealed the presence of at least six conserved regions between these chromosomes.

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