## Abstract A computer model of blood plasma which has allowed the effect of Gd(III) contrast agents to be simulated has been developed. Initial binding of Gd(III) is to transferrin. At high concentration the metal ion binds to citrate and salicylate. At a concentrate of 10^−3^ __M__, GdCl~3~ is pr
A Pyrophosphate-Responsive Gadolinium(III) MRI Contrast Agent
✍ Scribed by Dr. Andrew J. Surman; Dr. Célia S. Bonnet; Dr. Mark P. Lowe; Gavin D. Kenny; Prof. Jimmy D. Bell; Dr. Éva Tóth; Dr. Ramon Vilar
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 420 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0947-6539
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## Abstract The advantages and disadvantages of a number of paramagnetic Fe(III)‐containing MRI contrast agents are discussed. © 1991 Academic Press, Inc.
## Abstract A novel, radical responsive MRI contrast agent based on a gadolinium chelate conjugated to a liposome through a disulfide linker was synthesized, with the aim of pursuing the __in vivo__ mapping of radicals. The liposome was prepared by incorporating a thiol‐activated phospholipid, whic
We are grateful to Drs. Marzella, Blank, Gelperin, and Johann-Liang of the U.S. Food and Drug Administration for providing a timely update/reminder on the evolving safety concerns related to gadolinium and especially to Gadodiamide's association with nephrogenic systemic fibrosis (NSF) as well as th