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A proton NMR investigation of proline-24 cis-trans isomerism in corticotropin1–32 and related peptides

✍ Scribed by Flavio Toma; Serge Fermandjian; M. Löw; Lajos Kisfaludy


Book ID
113125818
Publisher
Elsevier Science
Year
1978
Weight
583 KB
Volume
534
Category
Article
ISSN
0005-2795

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The cyclic hexapeptide cycle[ -Pro'-Gly2-Glu3 (OBzl) -Pro4-Phe5-Leu6-] ( 1 ; OBzl: benzyl ester) was modeled and synthesized to be used as a chiral site for the separation of enantiomers. Total correlation spectroscopy and nuclear Ovehauser effect spectroscopy spectra of the peptide in CDCIB showed