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A Protective Role of PKCϵ against TNF-Related Apoptosis-Inducing Ligand (TRAIL)-Induced Apoptosis in Glioma Cells

✍ Scribed by Hisaaki Shinohara; Nobuhiko Kayagaki; Hideo Yagita; Naoki Oyaizu; Motoi Ohba; Toshio Kuroki; Yoji Ikawa

Book ID: 115588171
Publisher: Elsevier Science
Year: 2001
Tongue: English
Weight: 222 KB
Volume: 284
Category: Article
ISSN: 0006-291X
DOI: 10.1006/bbrc.2001.5104

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## Abstract Tumor necrosis factor (TNF)‐related apoptosis‐inducing ligand (TRAIL) induces apoptosis in a number of tumorogenic or transformed cells, yet is relatively non‐toxic to most normal cells, therefore, it is a promising agent for cancer therapy. However, some cancer cell lines were resistan