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A protective role for proteinase activated receptor 2 in airways of lipopolysaccharide-treated rats

โœ Scribed by Silvana Morello; Valentina Vellecco; Fiorentina Roviezzo; Pasquale Maffia; Salvatore Cuzzocrea; Giuseppe Cirino; Carla Cicala


Book ID
113487790
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
312 KB
Volume
71
Category
Article
ISSN
0006-2952

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## Abstract ## Objective Serine proteinases activate the G proteinโ€“coupled receptor, proteinaseโ€activated receptor 2 (PARโ€2), via cleavage and exposure of a tethered ligand. PARโ€2 is known to exert proinflammatory actions in a murine model of arthritis, since PARโ€2โ€“deficient mice exhibit strikingl