Expression and proinflammatory role of p
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Elizabeth B. Kelso; William R. Ferrell; John C. Lockhart; Iona Elias-Jones; Todd
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Article
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2007
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John Wiley and Sons
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English
⚖ 221 KB
👁 1 views
## Abstract ## Objective Serine proteinases activate the G protein–coupled receptor, proteinase‐activated receptor 2 (PAR‐2), via cleavage and exposure of a tethered ligand. PAR‐2 is known to exert proinflammatory actions in a murine model of arthritis, since PAR‐2–deficient mice exhibit strikingl