Dobydroamiao acids are important constituents of oertain psptidr antibiotics l/ . Recently, the synthesis of dohydroalaaine and 2-aoylamiaocrotonate derivatives uas doscrib.d2! ~erine sad tbreoalne drrivativrs have boen convertad by ohloriaation reactioa with phosphorus peatachloride and subsequent
A protection scheme for the preparation of acid chlorides of serine and threonine
β Scribed by Ning Xi; Marco A. Ciufolini
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- French
- Weight
- 392 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0040-4039
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Practical syntheses of protected derivatives of the non-proteinogenic allo-threonines are decribed. The key step is enzymatic resolution of threonine diastereomers, produced on controlled epimerization of the a-carbon atom. The protected allo-threonines are obtained in good overall yield and can be