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A prostanoid receptor EP4 agonist enhances ectopic bone formation induced by recombinant human bone morphogenetic protein-2

✍ Scribed by Ryuichi Sasaoka; Hidetomi Terai; Hiromitsu Toyoda; Yuuki Imai; Ryo Sugama; Kunio Takaoka

Book ID: 116288382
Publisher: Elsevier Science
Year: 2004
Tongue: English
Weight: 480 KB
Volume: 318
Category: Article
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2004.04.080

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## Abstract Bone morphogenetic proteins (BMP) stimulate osteoblast differentiation by signal transduction via three BMP receptors (BMPR‐IA, ‐IB, and ‐II). Several growth factors, including transforming growth factor‐β1 (TGF‐β1), fibroblast growth factor‐2 (FGF‐2) and platelet‐derived growth factor‐