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A prospective study of urinary androgen levels and ovarian cancer

✍ Scribed by Jack Cuzick; J. C. Bulstrode; I. Stratton; B. S. Thomas; R. D. Bulbrook; J. L. Hayward

Publisher
John Wiley and Sons
Year
1983
Tongue
French
Weight
347 KB
Volume
32
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The three major urinary androgen metabolites, dehydroepiandrosterone (DHEA), androsterone (ANDRO), and aetiocholanolone (AETIO) were measured in 1,484 volunteer women between 29 and 60 years of age on the island of Guernsey from 1962–1967. Twelve of these women subsequently developed ovarian cancer after a median interval of 130 months and a minimum interval of 19 months. All three androgen levels in these women were lower than those in controls matched for age and menopausal status. The results were most striking for DHEA, where half of the cases were below the 27th percentile of their matched controls (p = 0.007, two‐sided). The results for ANDRO were of marginal significance (p = 0.06), and those for AETIO were not significant (p= 0.033).

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