𝔖 Bobbio Scriptorium
✦   LIBER   ✦

A prospective study of serum sex hormones during carbamazepine therapy

✍ Scribed by Jouko I.T. Isojärvi; Arto J. Pakarinen; Vilho V. Myllylä

Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
444 KB
Volume
9
Category
Article
ISSN
0920-1211

No coin nor oath required. For personal study only.

✦ Synopsis

This paper reports the results of a 12-month prospective follow-up study on the effects of carbamazepine (CBZ) medication on serum sex and pituitary hormone concentrations in 21 male patients with recently diagnosed epilepsy. The results of the present study indicate that a change occurs in the androgen balance during CBZ medication in male patients with epilepsy: a rise in serum sex hormone binding globulin levels results in decreased free androgen index values, and dehydroepiandrosterone sulfate serum levels decrease. Serum testosterone and free testosterone levels remain unchanged, but estradiol levels decrease. Serum basal prolactin (PRL) levels remain unchanged, but the PRL responses to thyrotropin-releasing hormone and metoclopramide increase slightly during the first year of CBZ medication. Basal and stimulated serum gonadotropin levels remain unchanged. The clinical consequences of these hormonal changes during CBZ medication call for further studies.

📜 SIMILAR VOLUMES

Endogenous sex hormones and the risk of
Endogenous sex hormones and the risk of prostate cancer: A prospective study
✍ Jocelyn M. Weiss; Wen-Yi Huang; Sabina Rinaldi; Thomas R. Fears; Nilanjan Chatte 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 French ⚖ 95 KB 👁 2 views

## Abstract Sex steroid hormones influence prostate development and maintenance through their roles in prostate cellular proliferation, differentiation and apoptosis. Although suspected to be involved in prostate carcinogenesis, an association between circulating androgens and prostate cancer has n

Postmenopausal levels of sex hormones an
Postmenopausal levels of sex hormones and risk of breast carcinoma in situ: Results of a prospective study
✍ Anne Zeleniuch-Jacquotte; Yian Gu; Roy E. Shore; Karen L. Koenig; Alan A. Arslan 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 75 KB 👁 2 views

## Abstract We report on a prospective study to assess the association of postmenopausal serum levels of sex hormones with subsequent risk of breast carcinoma __in situ__. We conducted a case‐control study nested within the cohort of the New York University Women's Health Study, a large prospective

Early results of a prospective study of
Early results of a prospective study of hormone therapy for patients with locally advanced prostate carcinoma
✍ Jackson E. Fowler Jr.; Steven A. Bigler; John M. Kolski; David T. Yee 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 85 KB 👁 3 views

## Background: Locally advanced prostate carcinoma is usually not curable with surgery or radiation therapy. primary hormone therapy is an alternative therapeutic option, but contemporary prospective studies of the outcomes of such therapy are not available. ## Methods: The authors conducted a pr

Serum testosterone and sex hormone-bindi
Serum testosterone and sex hormone-binding globulin concentrations and the risk of prostate carcinoma : A longitudinal study
✍ Ritva Heikkilä; Kimmo Aho; Markku Heliövaara; Matti Hakama; Jukka Marniemi; Antt 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 60 KB 👁 2 views

## BACKGROUND. It has been hypothesized that high androgen levels are determinants of prostate carcinoma. ## METHODS. Serum concentrations of testosterone, sex hormone-binding globulin (SHBG), and androstenedione were analyzed to determine their role as predictors of prostate carcinoma in a lon

Mucosal healing in patients with ulcerat
Mucosal healing in patients with ulcerative colitis during a course of selective leukocytapheresis therapy: A prospective cohort study
✍ Takayuki Yamamoto; Satoru Umegae; Koichi Matsumoto 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 270 KB

Background: During active ulcerative colitis (UC), vast numbers of granulocytes, monocytes/macrophages (GM) infiltrate the mucosal tissue and can potentially exacerbate inflammation and injury. Accordingly, we were interested to see if selective depletion of GM by adsorption (GMA) impacts mucosal he