A prospective longitudinal analysis of cytomegalovirus (CMV)-specific CD4+ and CD8+ T cells in kidney allograft recipients at risk of CMV infection
✍ Scribed by Albert J Eid; Robert A Brown; Supha K Arthurs; Brian D Lahr; Jeanette E Eckel-Passow; Timothy S Larson; Raymund R Razonable
- Book ID
- 110917358
- Publisher
- Springer
- Year
- 2009
- Tongue
- English
- Weight
- 231 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0934-0874
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## Abstract The dynamics of CMV pp65 and IE‐1‐specific IFNγ‐producing CD8^+^ (IFNγ CD8^+^) and CD4^+^ (IFNγ CD4^+^) T cells and CMV DNAemia were assessed in 19 pre‐emptively treated episodes of active CMV infection. Peripheral counts of IFNγ CD8^+^ and IFNγ CD4^+^ T cells inversely correlated with
## Abstract Immune mechanisms involved in control of cytomegalovirus (CMV) infection in the allogeneic stem cell transplantation setting have not been fully disclosed. CMV pp65 and IE‐1‐specific CD8^+^ T cells expressing IFN‐γ, TNF‐α, and CD107a, alone or in combination, and NKG2C^+^ NK cells were