Kinetics of interferon-gamma producing cytomegalovirus (CMV)-specific CD4+ and CD8+ T lymphocytes and the risk of subsequent CMV viremia after allogeneic hematopoietic stem cell transplantation
✍ Scribed by A.J. Eid; R.A. Brown; W.J. Hogan; B.D. Lahr; J.E. Eckel-Passow; M.R. Litzow; R.R. Razonable
- Book ID
- 110904352
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 259 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1398-2273
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## Abstract We studied the recovery of CMV‐specific CD4^+^ and CD8^+^ T‐cell immunity in 52 recipients of allogeneic stem cell transplantation (SCT). The proportions of IFN‐γ‐producing CD4^+^ and CD8^+^ T cells upon in vitro activation using peptide pools representing the CMV pp65 and IE‐1 proteins
## Abstract Immune mechanisms involved in control of cytomegalovirus (CMV) infection in the allogeneic stem cell transplantation setting have not been fully disclosed. CMV pp65 and IE‐1‐specific CD8^+^ T cells expressing IFN‐γ, TNF‐α, and CD107a, alone or in combination, and NKG2C^+^ NK cells were
## Abstract The dynamics of CMV pp65 and IE‐1‐specific IFNγ‐producing CD8^+^ (IFNγ CD8^+^) and CD4^+^ (IFNγ CD4^+^) T cells and CMV DNAemia were assessed in 19 pre‐emptively treated episodes of active CMV infection. Peripheral counts of IFNγ CD8^+^ and IFNγ CD4^+^ T cells inversely correlated with
## Abstract Reconstitution of human cytomegalovirus (HCMV) T‐cell immunity is crucial in hematopoietic stem cell transplant (HSCT) recipients. The QuantiFERON®‐CMV assay for cellular HCMV‐specific immunity was evaluated in allogeneic HSCT recipients (n = 43) and patients with hematological malignan