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A promotor polymorphism in the Interleukin 11 gene is associated with chronic obstructive pulmonary disease

✍ Scribed by Wolfram Klein; Gernot Rohde; Umut Arinir; Michaela Hagedorn; Natascha Dürig; Gerhard Schultze-Werninghaus; Jörg T. Epplen

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
74 KB
Volume
25
Category
Article
ISSN
0173-0835

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✦ Synopsis

Abstract

Chronic obstructive pulmonary disease (COPD) is a multifactorial disorder characterized by irreversible airflow obstruction due to chronic inflammation. Hence, the gene encoding the anti‐inflammatory cytokine IL 11 is a good candidate for being involved in the genetic predisposition to COPD. In order to evaluate the role of the Interleukin 11 (IL 11) gene in the genetic predisposition for COPD, a dinucleotide microsatellite polymorphism in the promoter region has been genotyped in 153 patients with COPD (including 25 non‐smokers) and 463 healthy controls. Frequencies of the IL 11.A2 microsatellite allele and of IL 11.A2 homozygous individuals were significantly decreased among the patients with COPD (p < 0.012 and p < 0.022, respectively) as compared to controls. Both frequencies were even more drastically reduced among the nonsmoking patients. Tight linkage of this microsatellite allele with another polymorphism in the promotor region was established. Altered expression of IL 11 may be involved in the genetic predisposition to COPD.

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