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A program to calculate the isoelectric point of macromolecules

✍ Scribed by João Meireles Ribeiro; Antonio Sillero

Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
879 KB
Volume
21
Category
Article
ISSN
0010-4825

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✦ Synopsis

A program containing 260 sentences, written in BASIC and adapted to be run in personal computers, has been developed to calculate isoelectric point values of macromolecules (proteins, nucleic acids, polysaccharides, etc.). This implies the calculation of the coefficients and roots of a particular kind of polynomial. With common personal computers and using a compiled version of the program, the time required to calculate plvalues of macromolecules containing for example, 9,12, and 18 acid-base residues with different pKvalues was around 10 s, 2 min, and 2 h respectively.

BASIC interpreters Polynomial functions

Isoelectric point

Microcomputer program

📜 SIMILAR VOLUMES

An algorithm for the computer calculatio
An algorithm for the computer calculation of the coefficients of a polynomial that allows determination of isoelectric points of proteins and other macromolecules
✍ João Meireles Ribeiro; Antonio Sillero 📂 Article 📅 1990 🏛 Elsevier Science 🌐 English ⚖ 623 KB

The isoelectric point (~1) of a macromolecule containing any number of acid-base residues can be expressed as a polynomial whose coefficients are related to both the number of acid-base residues present in the molecule and their K values. Polynomials of degree higher than 5 are too complicated to be