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An algorithm for the computer calculation of the coefficients of a polynomial that allows determination of isoelectric points of proteins and other macromolecules

✍ Scribed by João Meireles Ribeiro; Antonio Sillero

Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
623 KB
Volume
20
Category
Article
ISSN
0010-4825

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✦ Synopsis

The isoelectric point (~1) of a macromolecule containing any number of acid-base residues can be expressed as a polynomial whose coefficients are related to both the number of acid-base residues present in the molecule and their K values. Polynomials of degree higher than 5 are too complicated to be solved manually. An algorithm is here presented which allows, with few sentences written in BASIC, the calculation of the polynomial coefficients. With this knowledge and using standard polynomial solving programs. the isoelectric point of the macromolecule can be calculated. Isoelectric point Proteins Microcomputer program Polynomial functions

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