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A proflavin-induced frameshift hotspot in the thymidylate synthase gene of bacteriophage T4

โœ Scribed by Michael D. Brown; Lynn S. Ripley; Dwight H. Hall


Book ID
113194405
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
718 KB
Volume
286
Category
Article
ISSN
0027-5107

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A hotspot for transition mutations in th
โœ Singer, Britta Swebilius ๐Ÿ“‚ Article ๐Ÿ“… 1984 ๐Ÿ› Springer ๐ŸŒ English โš– 729 KB

We have previously demonstrated that the sequence 5'TGGCAA 3' located at codons 32-33 of the rIIB gene of bacteriophage T4 is a hotspot for transition mutations (Nelson et al. 1981). Here I report the properties of the same TGGCAA sequence introduced into the gene at codons 11-12. The sequence is hi