A procedure for the facile syntheis of amino-acid N-carboxyanhydrides
β Scribed by William D. Fuller; Michael S. Verlander; Murray Goodman
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 1976
- Tongue
- English
- Weight
- 186 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0006-3525
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π SIMILAR VOLUMES
We have developed a novel method that effectively identifies the N-terminal product ions produced in the tandem mass spectrometry (MS/MS) analysis of peptides done in conjunction with the specific derivatization of the N-terminal amino group using 5-bromonicotinic acid N-hydroxysuccinimide ester (Br
## Abstract Amino acids with __N__βalkylaminooxy side chains have proven effective for the rapid synthesis of neoglycopeptides. Chemoselective reaction of reducing sugars with peptides containing these amino acids provides glycoconjugates that are structurally similar to their natural counterparts.
The conjugation of benzoyl-CoA with the aliphatic and acidic amino acids by glycine N-acyltransferase, as well as the amides of the latter group, was investigated. Bovine and human liver benzoylamino acid conjugation were investigated using electrospray ionization tandem mass spectrometry (ESI-MS-MS