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A procedure for computer analysis of data from macromolecule-ligand binding studies

โœ Scribed by John E. Fletcher; Arthur A. Spector

Publisher
Elsevier Science
Year
1968
Tongue
English
Weight
570 KB
Volume
2
Category
Article
ISSN
0010-4809

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โœฆ Synopsis

A procedure for fitting macromolecule-ligand binding data to a mathematical model using computer techniques is described. The computer algorithm for carrying out this procedure together with a flow diagram of the main program are presented. Using this procedure. the choice of an appropriate model is made from computed results, and the subjective bias often associated with hand-drawn graphical methods is avoided. In addition, estimates of the statistical standard errors of the binding constants are obtained. and information concerning the validity of the model is provided. The output obtained from the computer is displayed in both tabular and graphical form.

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