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A practical, two-stage preparation of benzyl (3R)-3-amino-2-oxo-1-pyrrolidinecarboxylate (2S,3S)-2,3-bis[(4-methylbenzoyl)oxy]butanediote (2:1)

✍ Scribed by Roger Barrett; Darren M Caine; Kevin S Cardwell; Jason W.B Cooke; Ron M Lawrence; Peter Scott; Åsa Sjolin

Book ID: 104360018
Publisher: Elsevier Science
Year: 2003
Tongue: English
Weight: 145 KB
Volume: 14
Category: Article
ISSN: 0957-4166
DOI: 10.1016/s0957-4166(03)00546-9

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✦ Synopsis

A convenient, efficient and cost-effective two-stage synthesis of benzyl (3R)-3-amino-2-oxo-1-pyrrolidinecarboxylate (2S,3S)-2,3-bis[(4-methylbenzoyl)oxy]butanediote (2:1) via a crystallisation-induced dynamic resolution process is reported.

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