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A practical synthesis of ethyl 1,2,4-triazole-3-carboxylate and its use in the formation of chiral 1′,2′-seco-nucleosides of ribavirin

✍ Scribed by Purushotham Vemishetti; Robert W. Leiby; Elie Abushanab; Raymond P. Panzica


Book ID
112128902
Publisher
Journal of Heterocyclic Chemistry
Year
1988
Tongue
English
Weight
273 KB
Volume
25
Category
Article
ISSN
0022-152X

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Synthesis and Application of a Novel Coupling Reagent, Ethyl 1-Hydroxy-1H-1,2,3-triazole-4-carboxylate. -A variety of Nhydroxylated 1,2,3-triazoles and imidazoles including the title compound (IX) are prepared. (IX) is an optimal reagent for solid-phase synthesis using Fmoc chemistry. It does not a