A practical synthesis of 3(S)-methyl-heptanoic acid from (S)-citronellol
β Scribed by Ralph Breitenbach; Charles K.-F. Chiu; Stephen S. Massett; Morgan Meltz; C.William Murtiashaw; Susan L. Pezzullo; Thomas Staigers
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 487 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0957-4166
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β¦ Synopsis
Chiral 3-methyl-heptanoic acid is readily accessible by functional group manipulation of optically active cimmellol. In principle, this approach is general and could be applied to the synthesis of chiral 3-methylalkanoic acids seven carbon atoms in length and longer.
π SIMILAR VOLUMES
An efficient synthesis of (S)-a-benzyl-a-methyl-b-alanine in 59% overall yield from benzaldehyde and methyl cyanoacetate has been developed. Enantioconvergent approaches to the synthesis of the target a,a-disubstituted b-amino acid from both enantiomers of previously resolved 2-cyano-2-methyl-3-phen