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A Practical Route to Enantiopure, Highly Functionalized Seven-Membered Carbocycles and Tetrahydrofurans: Concise Synthesis of (+)-Nemorensic Acid

✍ Scribed by Fernando López; Luis Castedo; José L. Mascareñas


Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
19 KB
Volume
8
Category
Article
ISSN
0947-6539

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A Practical Route to Enantiopure, Highly
✍ Fernando López; Luis Castedo; José L. Mascareñas 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 340 KB 👁 1 views

Highly diastereoselective thermal [5C2C] intramolecular pyrone ± alkene cycloadditions can be achieved by introducing a homochiral ptolylsulfinyl group at a suitable position of the alkene. The resulting adducts can be readily desulfinylated to give optically active 8-oxabicyclo[3.2.1]octane derivat