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A practical preparation of (R)- and (S)-N-Boc-2-methylpiperidines

✍ Scribed by Darío Doller; Robert Davies; Samuel Chackalamannil

Book ID: 104361147
Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 270 KB
Volume: 8
Category: Article
ISSN: 0957-4166
DOI: 10.1016/s0957-4166(97)00123-7

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✦ Synopsis

The resolution of (_+)-2-methylpiperidine using D-and L-tartaric acid followed by direct conversion of the intermediate tartrate salts to (R) and (S)-N-Boc-2methylpiperidine is described. Also described is an NMR protocol for assessing the optical purity of the intermediate tartrate salts as well as the free bases. The resolved enantiomers showed an ee of >98% based on NMR integration. (~)

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