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Synthesis of Methyl N -Boc-(2 S ,4 R )-4-methylpipecolate

โœ Scribed by Hung, Kuo-yuan; Harris, Paul W. R.; Brimble, Margaret A.


Book ID
127128631
Publisher
American Chemical Society
Year
2010
Tongue
English
Weight
915 KB
Volume
75
Category
Article
ISSN
0022-3263

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Synthesis of (2S,4S,5S)-5-hydroxy-4-meth
โœ Claus Herdeis; Eberhard Heller ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 487 KB

4S,5S)-5-hydroxy-4-methylpiperidine-2-one 4, readily available from Sglutamic acid, serves as a starting material for the synthesis of (2S,4S,5S)-5-hydroxy-4methylpipecolic acid 12. The key step of this reaction sequence is the chemoselective methylenation of the amide carbonyl group of 6 with dimet