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✦ LIBER ✦
A practical preparation of aryl β-ketophosphonates
✍ Scribed by Robert R. Milburn; Ken McRae; Johann Chan; Jason Tedrow; Robert Larsen; Margaret Faul
- Book ID
- 104096076
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- French
- Weight
- 142 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
The condensation of alkyl phosphonates with aryl esters to give b-ketophosphonates may be carried out at elevated temperatures mediated by LiHMDS under Barbier type conditions. The reaction is scalable, does not require specialized cryogenic equipment, and is general for all aryl and heteroaryl esters examined.
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