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A potentially hazardous interaction between erythromycin and midazolam

✍ Scribed by Olkkola, Klaus T; Aranko, Kari; Luurila, Harri; Hiller, Arja; Saarnivaara, Laila; Himberg, Jaakko-Juhani; Neuvonen, Pertti J

Book ID
109845250
Publisher
Nature Publishing Group
Year
1993
Tongue
English
Weight
524 KB
Volume
53
Category
Article
ISSN
0009-9236

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The interaction between roxithromycin and midazolam was investigated in a double-blind, randomised crossover study of two phases. Ten healthy volunteers were given roxithromycin (300 mg) or placebo once daily for 6 days. On the sixth day they ingested 15 mg midazolam. Plasma samples were collected a