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A potent and highly selective nonpeptidyl nociceptin/orphanin FQ receptor (ORL1) antagonist: J-113397

✍ Scribed by Satoshi Ozaki; Hiroshi Kawamoto; Yoshiki Itoh; Mitsuru Miyaji; Yoshikazu Iwasawa; Hisashi Ohta

Book ID: 114017743
Publisher: Elsevier Science
Year: 2000
Tongue: English
Weight: 91 KB
Volume: 387
Category: Article
ISSN: 0014-2999
DOI: 10.1016/s0014-2999(99)00822-5

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## Abstract The anti‐parkinsonian and levodopa‐sparing potential of the nociceptin/orphanin FQ receptor (NOP) antagonist J‐113397 has been demonstrated in rodent models of Parkinson's disease. Here, we describe the levodopa‐sparing potential of J‐113397 in MPTP‐lesioned marmosets. Coadministration