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In vitro characterization of J-113397, a non-peptide nociceptin/orphanin FQ receptor antagonist

✍ Scribed by R. Bigoni; G. Calo'; A. Rizzi; R. Guerrini; C. De Risi; Y. Hashimoto; E. Hashiba; D.G. Lambert; D. Regoli

Publisher
Springer-Verlag
Year
2000
Tongue
English
Weight
44 KB
Volume
361
Category
Article
ISSN
0028-1298

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The nociceptin/orphanin FQ (NOP) recepto
The nociceptin/orphanin FQ (NOP) receptor antagonist J-113397 enhances the effects of levodopa in the MPTP-lesioned nonhuman primate model of Parkinson's disease
✍ Naomi P. Visanji; Rob M.A. de Bie; Tom H. Johnston; Andrew C. McCreary; Jonathan 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 540 KB

## Abstract The anti‐parkinsonian and levodopa‐sparing potential of the nociceptin/orphanin FQ receptor (NOP) antagonist J‐113397 has been demonstrated in rodent models of Parkinson's disease. Here, we describe the levodopa‐sparing potential of J‐113397 in MPTP‐lesioned marmosets. Coadministration