๐”– Bobbio Scriptorium
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A POPULATION APPROACH TO INITIAL DOSE SELECTION

โœ Scribed by JON WAKEFIELD; STEPHEN WALKER

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
481 KB
Volume
16
Category
Article
ISSN
0277-6715

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โœฆ Synopsis

Before a drug can be marketed, an initial dose must be established. Sheiner et al. argue that a population approach leads to the most informed and rational decision making. We discuss the choice of an initial dose from both a predictive and estimative viewpoint. Our criteria are based upon evaluating the probabilities that a patient from the specified population obtains a response that is at least of a specified size. We demonstrate the approach using a simulation study and compare estimation of population parameters and initial dose using Bayesian and likelihood-based methods.

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