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A polymorphism in the matrix metalloproteinase-9 promoter is associated with increased risk of preterm premature rupture of membranes in African Americans

✍ Scribed by Ferrand, P. E.


Book ID
121720979
Publisher
Oxford University Press
Year
2002
Tongue
English
Weight
765 KB
Volume
8
Category
Article
ISSN
1360-9947

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A 12-bp deletion in the 5'-flanking regi
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We identified a novel 12-bp deletion NT\_033927.7: g.5495364\_5495375del in the 5'-flanking region of the SERPINH1 gene that increases promoter activity. The 12-bp deletion is in linkage disequilibrium with the minor "T" allele of the -656 C/T SNP (NT\_033927.7(SERPINH1):g.5495402C>T) that reduces p