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A polymorphism in the CCL2 chemokine gene is associated with asthma risk: a case–control and a family study in Tunisia

✍ Scribed by Chelbi, H; Ghadiri, A; Lacheb, J; Ghandil, P; Hamzaoui, K; Hamzaoui, A; Combadiere, C


Book ID
109852814
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
143 KB
Volume
9
Category
Article
ISSN
1466-4879

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CYP17 encodes the enzyme cytochrome P-450c17␣, which mediates both 17␣-hydroxylase and 17,20-lyase in the steroid biosynthesis pathway. A polymorphism in the 5 promoter region of the CYP17 gene has been described. Steroid hormones, especially androgens, are believed to play a key role in the etiolog