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A polymorphism in intron 6 of the CYP17 gene

โœ Scribed by L E. Crocitto; H. S. Feigelson; M. C. Yu; L. N. Kolonel; B. E. Henderson; G. A. Coetzee

Book ID
110887655
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
138 KB
Volume
52
Category
Article
ISSN
0009-9163

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CYP17 encodes the enzyme cytochrome P-450c17โฃ, which mediates both 17โฃ-hydroxylase and 17,20-lyase in the steroid biosynthesis pathway. A polymorphism in the 5 promoter region of the CYP17 gene has been described. Steroid hormones, especially androgens, are believed to play a key role in the etiolog