A polymorphism in a transporter of testosterone is a determinant of androgen independence in prostate cancer
β Scribed by Nima Sharifi; Akinobu Hamada; Tristan Sissung; Romano Danesi; David Venzon; Caitlin Baum; James L. Gulley; Douglas K. Price; William L. Dahut; William D. Figg
- Book ID
- 109054008
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 168 KB
- Volume
- 102
- Category
- Article
- ISSN
- 1464-4096
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Despite earlier detection and recent advances in surgery and radiation, prostate cancer is second only to lung cancer in male cancer deaths in the United States. Hormone therapy in the form of medical or surgical castration remains the mainstay of systemic treatment in prostate cancer.
TENB2 encodes a putative transmembrane proteoglycan, related to the EGF/heregulin family of growth factors and follistatin, which has been identified through the application of a differential display technique to a xenograft model of prostate cancer. Northern analysis and competitive PCR were used t